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Prof. Xu's flu virus research featured in the February 2011 issue of Chemistry World

posted May 4, 2011, 8:30 PM by Dong Xu   [ updated May 4, 2011, 8:35 PM ]
Quoted from an article published by Chemistry World, a prestigious journal from UK's Royal Society of Chemistry (RSC)...

The main difficulty with designing drugs to inhibit haemagglutinin binding is that the haemagglutinin receptor binding domain (RBD), which is the obvious target of such molecules, differs widely between serotypes. ‘We cannot expect a drug designed to target the haemagglutinin RBD of one influenza strain to be active against other strains’, says Dong Xu, assistant professor of chemistry at Boise State University, Idaho, US. Using molecular dynamics simulations, Xu has discovered that all RBDs bind to a common ‘fishhook like’ shape on the receptor surface. ‘We are now searching for compounds that mimic this glycan receptor shape’, he says. His group is also investigating the viability of designing molecules to target other sites on haemagglutinin...

See the full article here.